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Properties and catalytic mechanism of -glutamyltranspeptidase from NX-2
WANG Qian, YAO Zhong, XUN Zhijing, XU Xiaoying, XU Hong, WEI Ping
《化学科学与工程前沿(英文)》 2008年 第2卷 第4期 页码 456-461 doi: 10.1007/s11705-008-0075-3
关键词: catalytic mechanism mmol·min·L D-glutamine affinity parameter important practical
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells
Synat Kang, Yanyan Li, Yifeng Bao, Yi Li
《医学前沿(英文)》 2019年 第13卷 第1期 页码 69-82 doi: 10.1007/s11684-018-0677-1
Cytokine-activated T cells (CATs) can be easily expanded and are widely applied to cancer immunotherapy. However, the good efficacy of CATs is rarely reported in clinical applications because CATs have no or very low antigen specificity. The low-efficacy problem can be resolved using T cell antigen receptor-engineered CAT (TCR-CAT). Herein, we demonstrate that NY-ESO-1157–165 HLA-A*02:01-specific high-affinity TCR (HAT)-transduced CATs can specifically kill cancer cells with good efficacy. With low micromolar range dissociation equilibrium constants, HAT-transduced CATs showed good specificity with no off-target killing. Furthermore, the high-affinity TCR-CATs delivered significantly better activation and cytotoxicity than the equivalent TCR-engineered T cells (TCR-Ts) in terms of interferon-g and granzyme B production and in vitro cancer cell killing ability. TCR-CAT may be a very good alternative to the expensive TCR-T, which is considered an effective personalized cyto-immunotherapy.
关键词: cytokine-activated T cells high-affinity T cell receptor cancer immunotherapy TCR-CAT
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
《化学科学与工程前沿(英文)》 2014年 第8卷 第4期 页码 433-444 doi: 10.1007/s11705-014-1454-6
关键词: Alzheimer’s disease amyloid β-protein peptide inhibitors protein-protein interaction molecular dynamics simulation
Zhiyu ZHANG, Changxiao LIU, Duanyun SI, Rong LU, Xiulin YI
《化学科学与工程前沿(英文)》 2012年 第6卷 第4期 页码 436-442 doi: 10.1007/s11705-012-1222-4
PtHAK5, a candidate for mediating high-affinity K
Haili YANG, Weidan ZHANG, Weiwei CHAI, Wenying WANG, Li GAO, Jing ZHANG, Yongping WANG, Suo-Min WANG
《农业科学与工程前沿(英文)》 2018年 第5卷 第1期 页码 108-117 doi: 10.15302/J-FASE-2018200
关键词: K+ uptake PtHAK5 Puccinellia tenuiflora yeast complementation
《机械工程前沿(英文)》 2022年 第17卷 第4期 doi: 10.1007/s11465-022-0703-5
关键词: laser beam welding parameter optimization metamodel multi-objective
Pijush Samui, Jagan J
《结构与土木工程前沿(英文)》 2013年 第7卷 第2期 页码 133-136 doi: 10.1007/s11709-013-0202-1
关键词: unsaturated soil effective stress parameter Gaussian process regression (GPR) artificial neural network (ANN) variance
1000 MW ultra-supercritical turbine steam parameter optimization
FENG Weizhong
《能源前沿(英文)》 2008年 第2卷 第2期 页码 187-193 doi: 10.1007/s11708-008-0030-5
Structural parameter design method for a fast-steering mirror based on a closed-loop bandwidth
Guozhen CHEN, Pinkuan LIU, Han DING
《机械工程前沿(英文)》 2020年 第15卷 第1期 页码 55-65 doi: 10.1007/s11465-019-0545-y
关键词: fast-steering mirror structural parameter PI controller bandwidth notch filter
Energy efficient cutting parameter optimization
Xingzheng CHEN, Congbo LI, Ying TANG, Li LI, Hongcheng LI
《机械工程前沿(英文)》 2021年 第16卷 第2期 页码 221-248 doi: 10.1007/s11465-020-0627-x
关键词: energy efficiency cutting parameter optimization machining process
Hierarchical parameter estimation of DFIG and drive train system in a wind turbine generator
Xueping PAN, Ping JU, Feng WU, Yuqing JIN
《机械工程前沿(英文)》 2017年 第12卷 第3期 页码 367-376 doi: 10.1007/s11465-017-0429-y
A new hierarchical parameter estimation method for doubly fed induction generator (DFIG) and drive train system in a wind turbine generator (WTG) is proposed in this paper. Firstly, the parameters of the DFIG and the drive train are estimated locally under different types of disturbances. Secondly, a coordination estimation method is further applied to identify the parameters of the DFIG and the drive train simultaneously with the purpose of attaining the global optimal estimation results. The main benefit of the proposed scheme is the improved estimation accuracy. Estimation results confirm the applicability of the proposed estimation technique.
关键词: wind turbine generator DFIG drive train system hierarchical parameter estimation method trajectory sensitivity technique
Variational mode decomposition based modal parameter identification in civil engineering
Mingjie ZHANG, Fuyou XU
《结构与土木工程前沿(英文)》 2019年 第13卷 第5期 页码 1082-1094 doi: 10.1007/s11709-019-0537-3
关键词: modal parameter identification variational mode decomposition civil structure nonlinear system closely spaced modes
Shallow foundation response variability due to soil and model parameter uncertainty
Prishati RAYCHOWDHURY,Sumit JINDAL
《结构与土木工程前沿(英文)》 2014年 第8卷 第3期 页码 237-251 doi: 10.1007/s11709-014-0242-1
关键词: shallow foun dation sensitivity analysis centrifuge data first-order-second-moment (FOSM) method parameter uncertainty
Parameter studies on impact in a lap joint
Amir M. RAHMANI,Elizabeth K. ERVIN
《机械工程前沿(英文)》 2015年 第10卷 第1期 页码 64-77 doi: 10.1007/s11465-014-0322-x
To represent a loose lap joint, a beam impacting four springs with gaps is modeled. Modal analysis with base excitation is solved, and time histories of contact points are closely monitored. Using the impulse during steady state response, six influential parameters are studied: damping ratio, contact stiffness, intermediate contact position, gap, excitation amplitude and beam height. For all parameters, the system response is highly controlled by modes with two contacting springs. Each parameter’s effect on system response is presented including unstable regions, unique trend behaviours result. Recommendations for structural designers are also noted.
关键词: impact mechanics contact joint behaviour modal analysis parameter study
标题 作者 时间 类型 操作
Properties and catalytic mechanism of -glutamyltranspeptidase from NX-2
WANG Qian, YAO Zhong, XUN Zhijing, XU Xiaoying, XU Hong, WEI Ping
期刊论文
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells
Synat Kang, Yanyan Li, Yifeng Bao, Yi Li
期刊论文
Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-
Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG
期刊论文
LC/MS/MS and radioisotope method combined for recognizing the affinity between catalpol and OCT2 transporter
Zhiyu ZHANG, Changxiao LIU, Duanyun SI, Rong LU, Xiulin YI
期刊论文
PtHAK5, a candidate for mediating high-affinity K
Haili YANG, Weidan ZHANG, Weiwei CHAI, Wenying WANG, Li GAO, Jing ZHANG, Yongping WANG, Suo-Min WANG
期刊论文
Processing parameter optimization of fiber laser beam welding using an ensemble of metamodels and MOABC
期刊论文
Determination of effective stress parameter of unsaturated soils: A Gaussian process regression approach
Pijush Samui, Jagan J
期刊论文
Structural parameter design method for a fast-steering mirror based on a closed-loop bandwidth
Guozhen CHEN, Pinkuan LIU, Han DING
期刊论文
Energy efficient cutting parameter optimization
Xingzheng CHEN, Congbo LI, Ying TANG, Li LI, Hongcheng LI
期刊论文
Hierarchical parameter estimation of DFIG and drive train system in a wind turbine generator
Xueping PAN, Ping JU, Feng WU, Yuqing JIN
期刊论文
Variational mode decomposition based modal parameter identification in civil engineering
Mingjie ZHANG, Fuyou XU
期刊论文
Shallow foundation response variability due to soil and model parameter uncertainty
Prishati RAYCHOWDHURY,Sumit JINDAL
期刊论文